Lipid rafts clustering and signalling by listeriolysin O

被引：52

作者：

Gekara, NO ^{[1
]}

Weiss, S ^{[1
]}

机构：

[1] German Res Ctr Biotechnol, GBF, D-38124 Braunschweig, Germany

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

cholesterol; glycosylphosphatidylinositol anchor; lipid raft; Listeria monocytogenes; listeriolysin O; oligomerization;

D O I：

10.1042/BST0320712

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Listeriolysin O, the major virulent determinant of Listeria monocytogenes, is known for forming pores on cholesterol-rich membranes. In the present study, we reveal its other facet, rafts clustering. By immunofluorescence microscopy, we show that the glycosylphosphatidylinositol-anchored proteins CD14 and CD24, which normally exhibit uniform distribution on J774 cells, undergo clustering upon treatment with LLO. The non-raft marker transferrin receptor is unaffected by such treatment. Rafts clustering might explain the induction of tyrosine phosphorylation observed on LLO-treated cells.

引用

页码：712 / 714

页数：3

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