Impaired production of gastric ghrelin in chronic gastritis associated with Helicobacter pylori

被引:175
作者
Osawa, H
Nakazato, M
Date, Y
Kita, H
Ohnishi, H
Ueno, H
Shiiya, T
Satoh, K
Ishino, Y
Sugano, K
机构
[1] Jichi Med Sch, Dept Internal Med, Div Gastroenterol, Kawachi, Tochigi 3290498, Japan
[2] Miyazaki Med Coll, Dept Internal Med, Div 3, Miyazaki 8891692, Japan
关键词
D O I
10.1210/jc.2004-1330
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Ghrelin is primarily secreted from the stomach and has been implicated in the coordination of eating behavior and weight regulation. The effects of Helicobacter pylori infection on plasma ghrelin concentration and gastric ghrelin production still have not been well known. We determined plasma ghrelin concentration in a total of 160 consecutive individuals with normal body mass index including 110 H. pylori-infected and 50 H. pylori-negative subjects. The expression levels of ghrelin mRNA and ghrelin-producing cells in the gastric mucosa were quantified with real-time quantitative RT-PCR and immunohistochemistry, respectively. The severity of gastric atrophy was evaluated by serum pepsinogen concentrations. Plasma ghrelin concentration, gastric ghrelin mRNA, and ghrelin-positive cell numbers in gastric mucosa were significantly lower in H. pylori-infected subjects. The decrease in plasma ghrelin concentration in H. pylori-positive subjects was accompanied by an attenuation of ghrelin mRNA expression and a reduction of ghrelin-positive cell numbers in the gastric mucosa. Moreover, lower serum pepsinogen I concentrations and I/II ratio were significantly associated with lower plasma ghrelin concentrations in H. pylori-positive subjects. These findings suggest that impaired gastric ghrelin production in association with atrophic gastritis induced by H. pylori infection accounts for the decrease in plasma ghrelin concentration.
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收藏
页码:10 / 16
页数:7
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