Flaxseed and its mammalian lignan precursor cause a lengthening or cessation of estrous cycling in rats

被引：34

作者：

Orcheson, LJ ^{[1
]}

Rickard, SE ^{[1
]}

Seidl, MM ^{[1
]}

Thompson, LU ^{[1
]}

机构：

[1] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada

来源：

CANCER LETTERS | 1998年 / 125卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

flaxseed; mammalian lignans; secoisolariciresinol diglycoside; estrous cycle; antiestrogens;

D O I：

10.1016/S0304-3835(97)00482-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Flaxseed and its mammalian lignan precursor secoisolariciresinol diglycoside (SDG) have been shown to be mammary cancer-protective in rats. Thus, the antiestrogenic effects of flaxseed and SDG were compared with tamoxifen, an antiestrogen, by monitoring rat estrous cycling. Four-week supplementation of a high-fat diet with flaxseed (2.5, 5, or 10%) or SDG (0.75, 1.5 or 3.0 mg/day) produced a dose-related cessation or lengthening (by 18-39%) of estrous cycles in up to 66% of rats. With tamoxifen (1 mg/kg body weight/day), 83% of the animals had irregular cycles or were in persistent diestrus. Flaxseed and SDG were antiestrogenic without gross tissue toxicity. Published by Elsevier Science Ireland Ltd.

引用

页码：69 / 76

页数：8

共 49 条

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