Capillary electrochromatography-electrospray ionization mass spectrometry for the qualitative investigation of the drug etodolac and its metabolites in biological samples

被引：18

作者：

Strickmann, DB ^{[1
]}

Blaschke, G ^{[1
]}

机构：

[1] Univ Munster, Inst Pharmaceut Chem, D-48149 Munster, Germany

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2000年 / 748卷 / 01期

关键词：

electrochromatography; mass spectrometry; etodolac;

D O I：

10.1016/S0378-4347(00)00379-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

On-line coupling of capillary electrochromatography (CEC) with electrospray ionization (ESI) mass spectrometry (MS) was used for the qualitative investigation of the biotransformation of the non-steroidal anti-inflammatory drug etodolac. The coupling of this electro-driven separation technique with mass spectrometry allowed us to demonstrate the presence of different metabolites of etodolac extracted from human urine. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：213 / 219

页数：7

共 11 条

[1] Recent advances in capillary electrophoresis electrospray mass spectrometry [J].

Banks, JF .

ELECTROPHORESIS, 1997, 18 (12-13) :2255-2266

[2]

BECKERSCHARFENK.U, 1992, THESIS U MUNSTER

[3] EVALUATION OF THE STEREOSELECTIVE METABOLISM OF THE CHIRAL ANALGESIC DRUG ETODOLAC BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

BECKERSCHARFENKAMP, U ;

BLASCHKE, G .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1993, 621 (02) :199-207

[4] Capillary electrochromatography of biomolecules with on-line electrospray ionization and time-of-flight mass spectrometry [J].

Choudhary, G ;

Horváth, C ;

Banks, JF .

JOURNAL OF CHROMATOGRAPHY A, 1998, 828 (1-2) :469-480

[5]

Cikalo MG, 1998, ANALYST, V123, p87R

[6] Capillary electrochromatography [J].

Colon, LA ;

Guo, Y ;

Fermier, A .

ANALYTICAL CHEMISTRY, 1997, 69 (15) :A461-A467

[7]

FERDINANDI ES, 1987, DRUG METAB DISPOS, V15, P921

[8]

Kelly KA, 1998, CHEM ANAL SERIES MON, V146, P277

[9] Separation and identification of etodolac and its urinary phase I metabolites using capillary electrochromatography and on-line capillary electrochromatography-electrospray ionisation mass spectrometry coupling [J].

Strickmann, DB ;

Chankvetadze, B ;

Blaschke, G ;

Desiderio, C ;

Fanali, S .

JOURNAL OF CHROMATOGRAPHY A, 2000, 887 (1-2) :393-407

[10]

STRICKMANN DB, 2000, UNPUB J PHARM BIOMED

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