The undesirable lability of tert-butyldimethylsilyl ethers under Pd/C-catalyzed hydrogenation conditions and solution of the problem by using a Pd/C(en) catalyst

被引：51

作者：

Hattori, K ^{[1
]}

Sajiki, H ^{[1
]}

Hirota, K ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Med Chem Lab, Gifu 5025858, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 30期

关键词：

TBDMS ethers; desilylation; Pd/C; Pd/C(en); chemoselective hydrogenation;

D O I：

10.1016/S0040-4039(00)00935-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

While the frequent and unexpected loss of the TBDMS protective group of a variety of hydroxylic functions was demonstrated under neutral and mild hydrogenation conditions using 10% Pd/C, the undesirable problem was perfectly overcome by using a 10% Pd/C-ethylenediamine complex catalyst. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：5711 / 5714

页数：4

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