High throughput kinetic investigations of asymmetric hydrogenations with microdevices

被引：57

作者：

de Bellefon, C ^{[1
]}

Pestre, N

Lamouille, T

Grenouillet, P

Hessel, V

机构：

[1] ESCPE Lyon, CNRS, Lab Genie Procedes Catalyt, F-63100 Villeurbanne, France

[2] Inst Mikrotech Mainz, D-55129 Mainz, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2003年 / 345卷 / 1-2期

关键词：

asymmetric catalysis; high-throughput screening; homogeneous catalysis; kinetics; microreactors;

D O I：

10.1002/adsc.200390010

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

A high throughput test which is based on a micromachined mixer for molecular gas-liquid reactions was evaluated for the kinetic investigation of the asymmetric hydrogenation of methyl Z-(alpha)-acetamidocinamate with a rhodium/(S,S-BDPPTS) catalyst in an aqueous phase. Up to 214 tests were performed in a short time and with an average inventory of Rh/test as low as 14 mug. Comparisons with traditional batch experiments are provided.

引用

页码：190 / 193

页数：4

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