Lack of sensitization to the effects of d-amphetamine and apomorphine on sensorimotor gating in rats

被引:36
作者
Druhan, JP [1 ]
Geyer, MA
Valentino, RJ
机构
[1] Univ Penn, Dept Psychiat, Med Res Serv, Philadelphia Vet Adm Med Ctr, Philadelphia, PA 19104 USA
[2] Allegheny Univ Hlth Sci, Dept Psychiat, Philadelphia, PA 19102 USA
[3] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
关键词
prepulse inhibition; sensorimotor gating; sensitization; locomotor activity; amphetamine; apomorphine; schizophrenia; startle; dopamine rat;
D O I
10.1007/s002130050513
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This study assessed whether repeated injections of d-amphetamine or apomorphine could induce sensitization to the disruptive effects of these psychomotor stimulants on sensorimotor gating in rats, In the first experiment, rats were given six pre-exposures to either 2.0 mg/kg d-amphetamine or saline before being tested for the effects of d-amphetamine (0.0, 0.5, 1.0, 2.0 or 4.0 mg/kg, IF) on prepulse inhibition of acoustic startle (PPI) and locomotor activity. The tests for PPI confirmed that sensorimotor,eating could be disrupted by a high dose of il-amphetamine (4.0 mg/kg), However, comparison of the dose-response curves for the drug and saline pre-exposed groups did not reveal evidence for sensitization to this d-amphetamine effect in drug-pre-exposed rats, despite indications that sensitization had developed to the locomotor stimulant effects of LJ-amphetamine. A similar pattern of results was obtained in a second experiment that examined the effects of apomorphine (0.0, 0.1, 0.2, 0.4 and 0.8 mg/kg, SC) on PPI and locomotion in rats pre-exposed to 2.0 mg/kg of this drug or its vehicle, These findings demonstrate that treatments which induce sensitization to the behavioral activating effects of psychomotor stimulants do not necessarily produce sensitization to the disruptive effects of stimulants on sensorimotor gating. The implications of these results for hypotheses linking sensitization-like processes to the etiology of schizophrenia are discussed.
引用
收藏
页码:296 / 304
页数:9
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