The vasodilatory action of testosterone: a potassium-channel opening or a calcium antagonistic action?

被引：116

作者：

Jones, RD

Pugh, PJ

Jones, TH

Channer, KS

机构：

[1] Univ Sheffield, Sch Med, Div Genom Med,Endocrine Heart & Pituitary Grp, Acad Unit Endocrinol, Sheffield S10 2RX, S Yorkshire, England

[2] Royal Hallamshire Hosp, Sheffield Teaching Hosp NHS Trust, Dept Cardiol, Sheffield S10 2JF, S Yorkshire, England

[3] Barnsley Dist Gen Hosp, Barnsley Dist Gen Hosp NHS Trust, Ctr Diabet & Endocrinol, Barnsley S75 2EP, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2003年 / 138卷 / 05期

关键词：

testosterone; vasodilatation; vascular smooth muscle; coronary artery disease;

D O I：

10.1038/sj.bjp.0705141

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：733 / 744

页数：12

共 55 条

[1] The relationship of natural androgens to coronary heart disease in males: A review [J].

Alexandersen, P ;

Haarbo, J ;

Christiansen, C .

ATHEROSCLEROSIS, 1996, 125 (01) :1-13

[2] Testosterone induces Ca2+ influx via non-genomic surface receptors in activated T cells [J].

Benten, WPM ;

Lieberherr, M ;

Sekeris, CE ;

Wunderlich, F .

FEBS LETTERS, 1997, 407 (02) :211-214

[3] Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages [J].

Benten, WPM ;

Lieberherr, M ;

Stamm, O ;

Wrehlke, C ;

Guo, ZY ;

Wunderlich, F .

MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (10) :3113-3123

[4]

Brown TS, 1999, BT TELECOMM, V17, P291

[5] ESTROGEN RELAXES HUMAN EPICARDIAL CORONARY-ARTERIES THROUGH NON-ENDOTHELIUM-DEPENDENT MECHANISMS [J].

CHESTER, AH ;

JIANG, CW ;

BORLAND, JA ;

YACOUB, MH ;

COLLINS, P .

CORONARY ARTERY DISEASE, 1995, 6 (05) :417-422

[6] Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo [J].

Chou, TM ;

Sudhir, K ;

Hutchison, SJ ;

Ko, E ;

Amidon, TM ;

Collins, P ;

Chatterjee, K .

CIRCULATION, 1996, 94 (10) :2614-2619

[7] Antagonistic effects of 17β-estradiol, progesterone, and testosterone on Ca2+ entry mechanisms of coronary vasoconstriction [J].

Crews, JK ;

Khalil, RA .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (04) :1034-1040

[8] Gender-specific inhibition of Ca2+ entry mechanisms of arterial vasoconstriction by sex hormones [J].

Crews, JK ;

Khalil, RA .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1999, 26 (09) :707-715

[9] Effect of niflumic acid on noradrenaline-induced contractions of the rat aorta [J].

Criddle, DN ;

deMoura, RS ;

Greenwood, IA ;

Large, WA .

BRITISH JOURNAL OF PHARMACOLOGY, 1996, 118 (04) :1065-1071

[10] Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel [J].

Deenadayalu, VUP ;

White, RE ;

Stallone, JN ;

Gao, XM ;

Garcia, AJ .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (04) :H1720-H1727

← 1 2 3 4 5 6 →