Organization of vesicular trafficking in epithelia

被引：496

作者：

Rodriguez-Boulan, E

Kreitzer, G

Müsch, A

机构：

[1] Cornell Univ, Weill Med Coll, Margaret Dyson Vis Res Inst, New York, NY 10021 USA

[2] Cornell Univ, Weill Med Coll, Dept Cell & Dev Biol, New York, NY 10021 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 03期

关键词：

D O I：

10.1038/nrm1593

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Experiments using mammalian epithelial cell lines have elucidated biosynthetic and recycling pathways for apical and basolateral plasma-membrane proteins, and have identified components that guide apical and basolateral proteins along these pathways. These components include apical and basolateral sorting signals, adaptors for basolateral signals, and docking and fusion proteins for vesicular trafficking. Recent live-cell-imaging studies provide a real-time view of sorting processes in epithelial cells, including key roles for actin, microtubules and motors in the organization of post-Golgi trafficking.

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页码：233 / 247

页数：15

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