Activation of phospholipase C-gamma by the concerted action of tau proteins and arachidonic acid

被引:161
作者
Hwang, SC [1 ]
Jhon, DY [1 ]
Bae, YS [1 ]
Kim, JH [1 ]
Rhee, SG [1 ]
机构
[1] NHLBI, LAB CELL SIGNALING, NIH, BETHESDA, MD 20892 USA
关键词
D O I
10.1074/jbc.271.31.18342
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phospholipase C-gamma (PLC-gamma) isozymes are thought to be activated by receptor-induced tyrosine phosphorylation. Proteins that activate PLC-gamma 1 have now been purified from bovine brain and identified as members of the tan family of microtubule-associated proteins. Activation of PLC-gamma by tau was enhanced in the presence of unsaturated fatty acids such as arachidonic acid, saturated fatty acids being ineffective. Maximal (15-20-fold) activation was apparent in the presence of 0.15 mu M tau and 25 mu M arachidonic acid (AA). The effect of tau and AA was specific to PLC-gamma isozymes in the presence of submicromolar concentrations of Ca2+ and was markedly inhibited by phosphatidylcholine. These results suggest that in cells that express tau, receptor to cytosolic phospholipase A, may activate PLC-gamma isozymes indirectly in the absence of tyrosine phosphorylation through the hydrolysis of phosphatidylcholine to generate AA.
引用
收藏
页码:18342 / 18349
页数:8
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