Quaternary substituted PDE4 inhibitors I: The synthesis and in vitro evaluation of a novel series of oxindoles

被引：19

作者：

Hulme, C

Poli, GB

Huang, FC

Souness, JE

Djuric, SW

机构：

[1] Rhone Poulenc Rorer Cent Res, Collegeville, PA 19426 USA

[2] Rhone Poulenc Rorer Cent Res, Dagenham, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(97)10206-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The following letter presents the synthesis and in vitro evaluation of a novel quaternary substituted series of phosphodiesterase type (IV) (PDE4) inhibitors. The compounds represent conformationally constrained analogues of the Celltech PDE IV inhibitor, CDP 840. Examples with sub-micromolar IC50's for PDE4 inhibition are reported. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：175 / 178

页数：4

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