Association between the BDNF gene and schizophrenia

被引：68

作者：

Muglía, P

Vicente, AM

Verga, M

King, N

Macciardi, F

Kennedy, JL

机构：

[1] Univ Toronto, Ctr Addict & Mental Hlth, Neurogenet Sect, Dept Psychiat, Toronto, ON M5T 1R8, Canada

[2] Inst Gulbenkian Ciencias, Oeiras, Portugal

来源：

MOLECULAR PSYCHIATRY | 2003年 / 8卷 / 02期

关键词：

D O I：

10.1038/sj.mp.4001221

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Converging lines of evidence suggest that the brain-derived neurotrophic factor (BDNF) could be implicated in the neurodevelopmental abnormalities found in schizophrenia brain. BDNF is involved in a variety of trophic and neuromodulatory effects that include an important role in the development and survival of dopaminergic and serotonergic neurons. The authors showed the presence of association between a polymorphism in a promoter region of the BDNF gene and schizophrenia in a family-based linkage disequilibrium study.

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页码：146 / 147

页数：2

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