Corilagin inhibits the double strand break-triggered NF-κB pathway in irradiated microglial cells

Microglia. the resident immune Cells Of the central nervous system (CNS). are activated by various stimuli. Resting microglia are the basis of normal neurogenesis, while activated microglia may inhibit neurogenesis through the production of pro-inflammatory mediators and cytokines Remit research suggests that microglia are activated by irradiation This may play a role in radiation-induced brain injury (RIBI) DNA double-strand breaks (DSBs). the most deleterious Form of DNA damage after ionizing radiation. may rapidly trigger the activation of the NF-kappa B pathway via p53-induced protein leading to the release of pro-inflammatory mediators and cytokines Thus. it negative regulatory of the NF-kappa B pathway that Inhibits radiation-induced microglia activation could be used to treat RIBI. Corilagin. it member of the tannin family. Inhibits NF-kappa B pathway activation. In the present study. we examined the inhibitory effects of corilagin oil radiation-induced microglia activation using a variety of techniques. Our data suggest that corilagin inhibits radiation-induced microglia activation via suppression of the NF-kappa B Pathway and the compound is a potential treatment for RIBI