Selection-mutation process of RNA viruses

被引：4

作者：

Aafif, A ^{[1
]}

Lin, J ^{[1
]}

机构：

[1] Washington Coll, Dept Phys, Chestertown, MD 21620 USA

来源：

PHYSICAL REVIEW E | 1998年 / 57卷 / 02期

关键词：

D O I：

10.1103/PhysRevE.57.2471

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

RNA viruses mutate at a rate 10(5)-10(6) times faster than their DNA counterparts. This process can be simulated by a continuous stochastic model on a smooth one-dimensional fitness landscape where selection forces the viral quasispecies to climb uphill to higher fitness values. Theoretical results of the model with drift velocity proportional to fitness are fitted to the experimental observations made by Novella et al. [Proc. Natl. Acad. Sci. U.S.A. 92, 5841 (1995)].

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页码：2471 / 2474

页数：4

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