Flow cytometric characterization of lesional T cells in psoriasis:: intracellular cytokine and surface antigen expression indicates an activated, memory/effector type 1 immunophenotype

被引：73

作者：

Friedrich, M

Krammig, S

Henze, M

Döcke, WD

Sterry, W

Asadullah, K ^{[1
]}

机构：

[1] Schering AG, Expt Dermatol, D-133432 Berlin, Germany

[2] Humboldt Univ, Univ Hosp Charite, Dept Dermatol, D-10098 Berlin, Germany

[3] Humboldt Univ, Univ Hosp Charite, Dept Med Immunol, D-10098 Berlin, Germany

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 2000年 / 292卷 / 10期

关键词：

psoriasis; T cells; immunophenotypic characterization; CXCR3; cytokines;

D O I：

10.1007/s004030000167

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

[No abstract available]

引用

页码：519 / 521

页数：3

共 9 条

[1]

Asadullah K, 1999, DRUG TODAY, V35, P913

[2] IL-10 is a key cytokine in psoriasis -: Proof of principle by IL-10 therapy:: A new therapeutic approach [J].

Asadullah, K ;

Sterry, W ;

Stephanek, K ;

Jasulaitis, D ;

Leupold, M ;

Audring, H ;

Volk, HD ;

Döcke, WD .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (04) :783-794

[3] The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-γ, interleukin-2, and tumor necrosis factor-α, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations:: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients [J].

Austin, LM ;

Ozawa, M ;

Kikuchi, T ;

Walters, IB ;

Krueger, JG .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1999, 113 (05) :752-759

[4] The pathogenesis of psoriasis: Immunological facts and speculations [J].

Bos, JD ;

De Rie, MA .

IMMUNOLOGY TODAY, 1999, 20 (01) :40-46

[5] DETECTION OF A GAMMA-INTERFERON-INDUCED PROTEIN IP-10 IN PSORIATIC PLAQUES [J].

GOTTLIEB, AB ;

LUSTER, AD ;

POSNETT, DN ;

CARTER, DM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (03) :941-948

[6] Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes [J].

Sallusto, F ;

Lenig, D ;

Mackay, CR ;

Lanzavecchia, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (06) :875-883

[7] Identification and quantitation of interferon-γ producing T cells in psoriatic lesions:: Localization to both CD4+ and CD8+ subsets [J].

Szabo, SK ;

Hammerberg, C ;

Yoshida, Y ;

Bata-Csorgo, Z ;

Cooper, KD .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 111 (06) :1072-1078

[8] THE CYTOKINE NETWORK IN LESIONAL AND LESION-FREE PSORIATIC SKIN IS CHARACTERIZED BY A T-HELPER TYPE-1 CELL-MEDIATED RESPONSE [J].

UYEMURA, K ;

YAMAMURA, M ;

FIVENSON, DF ;

MODLIN, RL ;

NICKOLOFF, BJ .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1993, 101 (05) :701-705

[9] T-LYMPHOCYTES DERIVED FROM SKIN-LESIONS OF PATIENTS WITH PSORIASIS-VULGARIS EXPRESS A NOVEL CYTOKINE PATTERN THAT IS DISTINCT FROM THAT OF T-HELPER TYPE-1 AND T-HELPER TYPE-2 CELLS [J].

VOLLMER, S ;

MENSSEN, A ;

TROMMLER, P ;

SCHENDEL, D ;

PRINZ, JC .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (10) :2377-2382

← 1 →