7-chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates as novel highly selective AMPA receptor antagonists

被引:48
作者
Catarzi, D
Colotta, V
Varano, F
Cecchi, L
Filacchioni, G
Galli, A
Costagli, C
Carlà, V
机构
[1] Univ Florence, Dipartimento Sci Farmaceut, I-50121 Florence, Italy
[2] Univ Florence, Dipartimento Farmacol Preclin & Clin, I-50134 Florence, Italy
关键词
D O I
10.1021/jm0009686
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:3824 / 3826
页数:3
相关论文
共 14 条
[1]  
[Anonymous], DRUG NEWS PERSPECT
[2]   AMPA receptor agonists, antagonists and modulators: their potential for clinical utility [J].
Bigge, CF ;
Nikam, SS .
EXPERT OPINION ON THERAPEUTIC PATENTS, 1997, 7 (10) :1099-1114
[3]   4,5-dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones:: Excitatory amino acid antagonists with combined glycine NMDA and AMPA receptor affinity [J].
Catarzi, D ;
Colotta, V ;
Varano, F ;
Cecchi, L ;
Filacchioni, G ;
Galli, A ;
Costagli, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (13) :2478-2484
[4]   AMPA receptor antagonists [J].
Chimirri, A ;
Gitto, R ;
Zappalà, M .
EXPERT OPINION ON THERAPEUTIC PATENTS, 1999, 9 (05) :557-570
[5]   Synthesis and biological evaluation of a series of quinazoline-2-carboxylic acids and quinazoline-2,4-diones as glycine-NMDA antagonists: A pharmacophore model based approach [J].
Colotta, V ;
Catarzi, D ;
Varano, F ;
Cecchi, L ;
Filacchioni, G ;
Galli, A ;
Costagli, C .
ARCHIV DER PHARMAZIE, 1997, 330 (05) :129-134
[6]   CARDIOTONIC AGENTS - SYNTHESIS AND CARDIOVASCULAR PROPERTIES OF NOVEL 2-ARYLBENZIMIDAZOLES AND AZABENZIMIDAZOLES [J].
GUNGOR, T ;
FOUQUET, A ;
TEULON, JM ;
PROVOST, D ;
CAZES, M ;
CLOAREC, A .
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (23) :4455-4463
[7]   Glycine-site NMDA receptor antagonists: An update [J].
Kulagowski, JJ .
EXPERT OPINION ON THERAPEUTIC PATENTS, 1996, 6 (10) :1069-1079
[8]  
KULAGOWSKI JJ, 1995, EXPERT OPIN THER PAT, V5, P1061
[9]   Pharmacological characterization of metabotropic glutamate receptors potentiating NMDA responses in mouse cortical wedge preparations [J].
Mannaioni, G ;
Carla, V ;
Moroni, F .
BRITISH JOURNAL OF PHARMACOLOGY, 1996, 118 (06) :1530-1536
[10]   Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging [J].
Michaelis, EK .
PROGRESS IN NEUROBIOLOGY, 1998, 54 (04) :369-415