A method for the kinetic study of amino acid nitrosation reactions

被引：9

作者：

Santos, MDG ^{[1
]}

Calle, E ^{[1
]}

Casado, J ^{[1
]}

机构：

[1] Univ Salamanca, Dept Quim Fis, E-37008 Salamanca, Spain

来源：

POLYHEDRON | 2003年 / 22卷 / 08期

关键词：

nitrosation; amino acid; dinitrogen trioxide; spectrophotometry;

D O I：

10.1016/S0277-5387(03)00091-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A method for the kinetic study of amino acid nitrosation reactions whose products are unstable is described. The reactions of NaNO2 with alpha-, beta-, and gamma-amino acids with a primary amino group in acidic media were studied spectrophotometrically by monitoring the absorbance of the nitrite. The experimental rate equation r = k(3exp)[amino acid][nitrite](2) was found. The second-order with respect to the nitrite concentration implies that dinitrogen trioxide would be the main nitrosating agent. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1059 / 1066

页数：8

共 16 条

[1] *C US, 1987, OTABPH42, P33
[2] Amino acid nitrosation products as alkylating agents
García-Santos, MD
Calle, E
Casado, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (31) : 7506 - 7510
[3] Gil R, 1997, INT J CHEM KINET, V29, P495, DOI 10.1002/(SICI)1097-4601(1997)29:7<495::AID-KIN3>3.0.CO
[4] 2-P
[5] THE NITROSATION OF AMINO-ACIDS
GIL, R
CASADO, J
IZQUIERDO, C
[J]. INTERNATIONAL JOURNAL OF CHEMICAL KINETICS, 1994, 26 (12) : 1167 - 1178
[6] Inhibition of nitrosation by steric hindrance
González-Mancebo, S
Calle, E
García-Santos, MP
Casado, J
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1997, 45 (02) : 334 - 336
[7] Lijinsky W., 1992, CHEM BIOL N NITROSO
[8] MARCH J, 1992, ADV ORG CHEM, P18
[9] HYDROLYSIS EQUILIBRIUM OF DINITROGEN TRIOXIDE IN DILUTE ACID-SOLUTION
MARKOVITS, GY
SCHWARTZ, SE
NEWMAN, L
[J]. INORGANIC CHEMISTRY, 1981, 20 (02) : 445 - 450
[10] NITROSATION OF ASPARTIC-ACID, ASPARTAME, AND GLYCINE ETHYLESTER - ALKYLATION OF 4-(PARA-NITROBENZYL)PYRIDINE (NBP) INVITRO AND BINDING TO DNA IN THE RAT
MEIER, I
SHEPHARD, SE
LUTZ, WK
[J]. MUTATION RESEARCH, 1990, 238 (03): : 193 - 201

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