Catalytic, highly enantioselective, direct amination of β-ketoesters

被引：188

作者：

Marigo, M ^{[1
]}

Juhl, K ^{[1
]}

Jorgensen, KA ^{[1
]}

机构：

[1] Aarhus Univ, Dept Chem, Danish Natl Res Fdn, Ctr Catalysis, DK-8000 Aarhus C, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 12期

关键词：

beta-ketoesters; amination; asymmetric catalysis; copper; synthetic methods;

D O I：

10.1002/anie.200390350

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Optically active α-amino acid derivatives were accessed through the direct asymmetric α-amination of α-substituted β-ketoesters 1, catalyzed by chiral CuII-bisoxazoline (BOX) complexes. The reaction proceeds with dibenzyl azodicarboxylate in the presence of only 0.2 mol% of the catalyst to give the desired products 2 in high yield with excellent enantioselectivity (up to 99% ee).

引用

页码：1367 / 1369

页数：3

共 59 条

[1]

Arend M, 1999, ANGEW CHEM INT EDIT, V38, P2873, DOI 10.1002/(SICI)1521-3773(19991004)38:19<2873::AID-ANIE2873>3.0.CO

[2]

2-P

[3]

AREND M, 1999, ANGEW CHEM, V111, P3047, DOI DOI 10.1002/(SICI)1521-3757(19991004)111:19<3047::AID-ANGE3047>3.0.CO

[4]

2-A