Expression of connexins in the normal and obstructed developing kidney

被引：16

作者：

Silverstein, DM

Thornhill, BA

Leung, JC

Vehaskari, VM

Craver, RD

Trachtman, HA

Chevalier, RL

机构：

[1] Louisiana State Univ, Div Nephrol, Dept Pediat, Hlth Sci Ctr, New Orleans, LA 70112 USA

[2] Louisiana State Univ, Div Neonatol, Dept Pediat, Hlth Sci Ctr, New Orleans, LA 70112 USA

[3] Univ Virginia, Dept Pediat, Charlottesville, VA USA

[4] Louisiana State Univ, Hlth Sci Ctr, Dept Pathol, New Orleans, LA 70112 USA

[5] Long Isl Jewish Med Ctr, Dept Pediat, New Hyde Pk, NY 11042 USA

来源：

PEDIATRIC NEPHROLOGY | 2003年 / 18卷 / 03期

关键词：

connexin; kidney development; neonatal; ureteral obstruction;

D O I：

10.1007/s00467-002-1065-1

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Connections between cells are achieved by proteins called connexins that comprise the gap junction. Connexins play a major role in organ development. Our reverse transcription-polymerase chain reaction (RTPCR) studies demonstrate that Cx30, Cx36, Cx37, Cx40, Cx45, Cx46, and Cx50 are expressed in the kidney. Quantitative RT-PCR indicates that Cx37, Cx45, and Cx46 are preferentially expressed during early renal development. We also explored the expression of connexins in neonatal unilateral ureteral obstruction (UUO). After 12 days of neonatal UUO, the renal mRNA expression of Cx30, Cx37, and Cx40 was significantly elevated. In contrast, there was no change in connexin renal mRNA levels in adult UUO. We conclude that multiple connexins are expressed in the rat kidney and several are aberrantly expressed in neonatal UUO.

引用

页码：216 / 224

页数：9

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