Synthesis of the alleged structure of sclerophytin A. The setting of two oxygen bridges within the fused cyclodecanol B ring is not nature's way

被引：54

作者：

Paquette, LA ^{[1
]}

Moradei, OM ^{[1
]}

Bernardelli, P ^{[1
]}

Lange, T ^{[1
]}

机构：

[1] Ohio State Univ, Evans Chem Labs, Columbus, OH 43210 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 13期

关键词：

D O I：

10.1021/ol000083o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structure attributed to sclerophytin A, a cytotoxic soft coral metabolite, was synthesized in an enantioselective manner from (5S)-5-(d-menthyloxy)-2(5H)-furanone. The spectral properties and polarity of the synthetic product require that the structural assignment to the natural material be revised.

引用

页码：1875 / 1878

页数：4

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