Successful targeting of ErbB2 receptors - is PTEN the key?

被引：27

作者：

Crowder, RJ

Lombardi, DP

Ellis, MJ

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Oncol, St Louis, MO 63110 USA

[2] Siteman Canc Ctr, St Louis, MO 63110 USA

来源：

CANCER CELL | 2004年 / 6卷 / 02期

关键词：

D O I：

10.1016/j.ccr.2004.08.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Women with ErbB2-positive breast cancer have a poor prognosis, and frequently, chemotherapy treatment is ineffective. The ErbB2-targeted antibody trastuzumab improves survival when given with chemotherapy to patients with ErbB2-over-expressing metastatic disease, but treatment is not curative, and primary resistance is common. Postulated mechanisms of action for trastuzumab include immune-mediated cytotoxicity and receptor downmodulation. A study in this issue of Cancer Cell suggests that trastuzumab causes rapid activation of the PTEN lipid phosphatase, which in turn downregulates the phosphatidylinositol 3'-kinase (PI3K) pathway. Resistance to trastuzumab occurs when PTEN function is lost, suggesting that PTEN activation is a critical component of the therapeutic effect.

引用

页码：103 / 104

页数：2

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