New hydrosoluble perylene and coronene derivatives

被引：49

作者：

Franceschin, M ^{[1
]}

Alvino, A ^{[1
]}

Ortaggi, G ^{[1
]}

Bianco, A ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 49期

关键词：

perylene; coronene; hydrosoluble; G-quadruplex; telomerase inhibitors;

D O I：

10.1016/j.tetlet.2004.10.040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several lipophilic perylene and coronene derivatives, employed mainly as liquid crystalline dyes are known and their synthesis has been widely studied. We have applied an analogue strategy using hydrophilic substituents to obtain highly water soluble perylene diimides (4) and a new hydrosoluble coronene derivative (CORON, 6), whose molecular features appear particularly suitable for inducing G-quadruplex DNA structures and inhibiting human telomerase. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9015 / 9020

页数：6

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