Potential use of non-classical pathways for the transport of macromolecular drugs

被引:15
作者
Kueltzo, LA [1 ]
Middaugh, CR [1 ]
机构
[1] Univ Kansas, Dept Pharmaceut Chem, Lawrence, KS 66047 USA
关键词
antennapedia; gene delivery; non-classical transport; protein delivery; Tat; VP22;
D O I
10.1517/13543784.9.9.2039
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Since an increasing number of drug delivery strategies utilising proteins and peptides exhibiting 'non-classical' transport activities have been proposed, studies have begun to establish underlying functional relationships between different vectors. These attempts to find common factors have been hampered by a lack of biophysical data for the various potential protein and peptide transporters, as well as by the structural and functional diversity of the group as a whole. We describe the various types of vectors being considered for use and the preliminary therapeutic successes that have been achieved. Additionally, the various models that have been proposed for non-classical import and export are outlined and discussed in relation to therapeutic delivery. Possible future developments are also discussed.
引用
收藏
页码:2039 / 2050
页数:12
相关论文
共 107 条
[1]  
Aints A, 1999, J GENE MED, V1, P275
[2]  
Albini A, 1996, ONCOGENE, V12, P289
[3]   DOWN-REGULATION OF AMYLOID PRECURSOR PROTEIN INHIBITS NEURITE OUTGROWTH IN-VITRO [J].
ALLINQUANT, B ;
HANTRAYE, P ;
MAILLEUX, P ;
MOYA, K ;
BOUILLOT, C ;
PROCHIANTZ, A .
JOURNAL OF CELL BIOLOGY, 1995, 128 (05) :919-927
[4]   Specificity of helix-induction by 2,2,2-trifluoroethanol in polypeptides [J].
Arunkumar, AI ;
Kumar, TKS ;
Yu, C .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1997, 21 (03) :223-230
[5]   Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo [J].
Ballard, JD ;
Collier, RJ ;
Starnbach, MN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (22) :12531-12534
[6]   Protein therapy - delivery guaranteed [J].
Bayley, H .
NATURE BIOTECHNOLOGY, 1999, 17 (11) :1066-+
[7]   Conformational and associative behaviours of the third helix of antennapedia homeodomain in membrane-mimetic environments [J].
Berlose, JP ;
Convert, O ;
Derossi, D ;
Brunissen, A ;
Chassaing, G .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 242 (02) :372-386
[8]  
BLAHO JA, 1994, J BIOL CHEM, V269, P17401
[9]   Lipid-assisted protein folding [J].
Bogdanov, M ;
Dowhan, W .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (52) :36827-36830
[10]   THE MOLTEN GLOBULE STATE IS INVOLVED IN THE TRANSLOCATION OF PROTEINS ACROSS MEMBRANES [J].
BYCHKOVA, VE ;
PAIN, RH ;
PTITSYN, OB .
FEBS LETTERS, 1988, 238 (02) :231-234