The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives

被引：276

作者：

Pavlovic, D

Neville, DCA

Argaud, O

Blumberg, B

Dwek, RA

Fischer, WB

Zitzmann, N

机构：

[1] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England

[2] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 10期

关键词：

D O I：

10.1073/pnas.1031527100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.

引用

收藏

页码：6104 / 6108

页数：5

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