Early maternal deprivation induces alterations in brain-derived neurotrophic factor expression in the developing rat hippocampus

被引：48

作者：

Kuma, H

Miki, T

Matsumoto, Y

Gu, H

Li, HP

Kusaka, T

Satriotomo, I

Okamoto, H

Yokoyama, T

Bedi, KS

Onishi, S

Suwaki, H

Takeuchi, Y

机构：

[1] Kagawa Univ, Fac Med, Dept Anat & Neurobiol, Miki, Kagawa 7610793, Japan

[2] Kagawa Univ, Fac Med, Dept Neuropsychiat, Miki, Kagawa 7610793, Japan

[3] Kagawa Univ, Fac Med, Dept Pediat, Miki, Kagawa 7610793, Japan

[4] Univ Queensland, Dept Anat & Dev Biol, Brisbane, Qld 4072, Australia

[5] Takamatsu Junior Coll, Dept Early Childhood Care & Educ, Takamatsu, Kagawa 7610194, Japan

来源：

NEUROSCIENCE LETTERS | 2004年 / 372卷 / 1-2期

关键词：

maternal separation; hippocampus; development; BDNF mRNA; real-time PCR;

D O I：

10.1016/j.neulet.2004.09.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of maternal deprivation (MD) during early postnatal life on the brain-derived neurotrophic factor (BDNF) level were investigated in the present study. Wistar rats were assigned to either maternal deprivation or mother-reared control (MRC) groups. MD manipulation was achieved by separating rat pups from their mothers for 3 h a day during postnatal days (PND) 10-15. At 16, 20, 30, and 60 days of age, the level of BDNF mRNA in the hippocampal formation of each group was determined using real-time PCR analysis. Early postnatal maternal deprivation of rat pups resulted in a significant increase in body weight at 60 days of age. The expression of BDNF mRNA in the hippocampus was significantly decreased at 16 days of age, and increased at 30 and 60 days of age. These data indicate that even a brief period of maternal deprivation during early postnatal life can affect hippocampal BDNF expression. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：68 / 73

页数：6

共 38 条

[1] Voluntary exercise protects against stress-induced decreased in brain-derived neurotrophic factor protein expression [J].