Antileishmanial cyclic peroxides from the Palauan sponge Plakortis aff. angulospiculatus

被引：66

作者：

Compagnone, RS

Piña, IC

Rangel, HR

Dagger, F

Suárez, AI

Reddy, MVR

Faulkner, DJ

机构：

[1] Cent Univ Venezuela, Fac Ciencias, Escuela Quim, Ctr Quim Organ, Caracas, Venezuela

[2] Cent Univ Venezuela, Fac Ciencias, Ctr Biol Celular, Caracas, Venezuela

[3] Cent Univ Venezuela, Fac Farm, Caracas, Venezuela

[4] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 13期

基金：

美国国家卫生研究院; 美国海洋和大气管理局;

关键词：

D O I：

10.1016/S0040-4020(98)00055-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As part of a program to discover new drugs for the treatment of tropical diseases, we have isolated and identified six new metabolites from the Palauan sponge Plakortis aff. angulospiculatus. Two cyclic peroxides show strong in vitro antiproliferative effects on promastigotes of Leishmania mexicana, a flagellate protozoan that causes leishmaniasis. The structures of the cyclic peroxides 1, 2 and 5 and furans 3, 4 and 6 were elucidated by interpretation of spectroscopic data, molecular modelling, and chemical interconversions. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3057 / 3068

页数：12

共 16 条

[1] ESTIMATION OF POPULATION AT RISK OF INFECTION AND NUMBER OF CASES OF LEISHMANIASIS [J].