Synthesis of 7α-hydroxy derivatives of regulatory oxysterols

被引：13

作者：

Li, DS ^{[1
]}

Spencer, TA ^{[1
]}

机构：

[1] Dartmouth Coll, Dept Chem, Hanover, NH 03755 USA

来源：

STEROIDS | 2000年 / 65卷 / 09期

关键词：

oxysterols; 7; alpha-hydroxyoxysterols; synthesis;

D O I：

10.1016/S0039-128X(00)00131-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

7 alpha-Hydroxy derivatives of oxysterols are of considerable interest because of their possible involvement in regulation of cholesterol metabolism This paper describes stereoselective syntheses and complete characterization of the 7 alpha-hydroxy derivatives of four key oxysterols: 25-hydroxycholesterol, 27-hydroxycholesterol, 24(S)-hydroxycholesterol, and 24(S),25-epoxycholesterol. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：529 / 535

页数：7

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