Expression of ETS-1 related to angiogenesis in uterine endometrium during the menstrual cycle

被引：22

作者：

Fujimoto, J ^{[1
]}

Aoki, I ^{[1
]}

Toyoki, H ^{[1
]}

Khatun, S ^{[1
]}

Sato, E ^{[1
]}

Tamaya, T ^{[1
]}

机构：

[1] Gifu Univ, Sch Med, Dept Obstet & Gynecol, Gifu 5008705, Japan

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2003年 / 10卷 / 03期

关键词：

angiogenesis; ets-1; uterine endometrium;

D O I：

10.1159/000070097

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ETS-1 has been identified as a transcription factor for angiogenesis, which is essential for the development and growth of the uterine endometrium. This characteristic prompted us to study whether ETS-1 functions as an angiogenic mediator in uterine endometrium. Immunohistochemical staining revealed that the localization of ETS-1 was similar to that of vascular endothelial cells. There was a significant correlation between microvessel counts and both ETS-1 histoscores and ets-1 mRNA levels in uterine endometrium. The ETS-1 histoscores and ets-1 mRNA levels increased in the proliferative phase, reached a peak during peri-ovulation and decreased in the secretory phase. Furthermore, the ETS-1 histoscores and ets-1 mRNA levels correlated with vascular endothelial growth factor (VEGF) levels in the proliferative phase. This indicates that ETS-1 might be an angiogenic mediator in uterine endometrium linked to VEGF in the proliferative phase. Copyright (C) 2003 National Science Council, ROC and S. Karger AG, Basel.

引用

页码：320 / 327

页数：8

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