Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer

被引：47

作者：

Gresner, Peter ^{[1
]}

Gromadzinska, Jolanta ^{[1
]}

Wasowicz, Wojciech ^{[1
]}

机构：

[1] Nofer Inst Occupat Med, Dept Toxicol & Carcinogenesis, PL-91348 Lodz, Poland

来源：

LUNG CANCER | 2007年 / 57卷 / 01期

关键词：

lung; cancer; genetic polymorphism; individual susceptibility; detoxifying enzymes; molecular epidemiology;

D O I：

10.1016/j.lungcan.2007.02.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Available data indicate that there are significant differences in individual susceptibility to lung cancer within the human population. It is believed to be underlie by inherited genetic predispositions related to the genetic polymorphism of several enzymes involved in the detoxification and xenobiotic metabolism. In this review, we collect and discuss the evidence reported up to date on the association between lung cancer and genetic polymorphism of cytochromes P450, N-acetyltransferase, glutathione S-transferases, microsomal epoxide hydrolase, NAD(P)H:quinone oxidoreductase, myeloperoxidase and glutathione peroxidase. All these genes might appear to be candidates for lung cancer susceptibility genes, nevertheless, the present state of the art still offers only a limited explanation of the link between such polymorphisms and increased risk of lung cancer. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 25

页数：25

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