Organochlorine pesticides and endometriosis

被引：36

作者：

Cooney, Maureen A. ^{[1
]}

Louis, Germaine M. Buck ^{[1
]}

Hediger, Mary L. ^{[1
]}

Vexler, Albert ^{[2
]}

Kostyniak, Paul J. ^{[3
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Epidemiol Stat & Prevent Res, Rockville, MD 20852 USA

[2] SUNY Buffalo, Dept Biostat, Buffalo, NY 14214 USA

[3] SUNY Buffalo, Dept Pharmacol & Toxicol, Sch Med & Biomed Sci, Buffalo, NY 14214 USA

来源：

REPRODUCTIVE TOXICOLOGY | 2010年 / 30卷 / 03期

关键词：

Endometriosis; Environment; Fecundity; Organochlorines; Pesticides; Reproductive toxicant; HIGH PLASMA-CONCENTRATIONS; POLYCHLORINATED-BIPHENYLS; ITALIAN WOMEN; SERUM-LEVELS; EXPOSURE; RISK;

D O I：

10.1016/j.reprotox.2010.05.011

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Limited study of persistent organochlorine pesticides (OCPs) and endometriosis has been conducted. One hundred women aged 18-40 years who were undergoing laparoscopy provided 20 cm(3) of blood for toxicologic analysis and surgeons completed operative reports regarding the presence of endometriosis. Gas chromatography with electron capture was used to quantify (ng/g serum) six OCPs. Logistic regression was utilized to estimate the adjusted odds ratios (aOR) and 95% confidence intervals (Cl) for individual pesticides and groups based on chemical structure adjusting for current cigarette smoking and lipids. The highest tertile of aromatic fungicide was associated with a fivefold risk of endometriosis (aOR = 5.3: 95% CI, 1.2-23.6) compared to the lowest tertile. Similar results were found for t-nonachlor and HCB. These are the first such findings in a laproscopic cohort that suggest an association between OCP exposure and endometriosis. More prospective studies are necessary to ensure temporal ordering and confirm these findings. Published by Elsevier Inc.

引用

页码：365 / 369

页数：5

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