Synthesis of 5,12-dioxocyclam nickel (II) complexes having quinoxaline substituents at the 6 and 13 positions as potential DNA bis-intercalating and cleaving agents

被引：49

作者：

Hegedus, LS ^{[1
]}

Greenberg, MM

Wendling, JJ

Bullock, JP

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

[2] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 11期

关键词：

D O I：

10.1021/jo020708r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several dioxocyclams containing quinoxaline moieties, as well as their nickel(II) complexes were synthesized and studied for their ability to bind and oxidatively cleave DNA. Although no evidence for binding by intercalation was found, the ability of the Ni(II) complexes to cleave DNA in the presence of Oxone was strongly dependent on both the nature and the spatial orientation of the quinoxaline moieties, suggesting at least transient association of these complexes with DNA.

引用

页码：4179 / 4188

页数：10

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