Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneti 2b

被引：248

作者：

Hata, M

Suzuki, M

Matsumoto, M

Takahashi, M

Sato, K

Ibe, S

Sakae, K

机构：

[1] Aichi Prefectural Inst Publ Hlth, Dept Microbiol, Kita Ku, Nagoya, Aichi, Japan

[2] Nagoya Med Ctr, Clin Res Ctr, Nagoya, Aichi, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 02期

关键词：

D O I：

10.1128/AAC.49.2.801-803.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A novel gene for quinolone resistance was cloned from a transferable plasmid carried by a clinical isolate of Shigella flexneri 2b that was resistant to fluoroquinolones. The plasmid conferred low-level resistance to quinolones on Escherichia coli HB101. The protein encoded by the gene showed 59% amino acid identity with Qnr.

引用

收藏

页码：801 / 803

页数：3

相关论文

共 12 条

[1] DNA gyrase, topoisomerase IV, and the 4-quinolones [J].

Drlica, K ;

Zhao, XL .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 1997, 61 (03) :377-+

[2] DNA-SEQUENCE ANALYSIS OF THE TRANSPOSON TN3 - 3 GENES AND 3 SITES INVOLVED IN TRANSPOSITION OF TN3 [J].

HEFFRON, F ;

MCCARTHY, BJ ;

OHTSUBO, H ;

OHTSUBO, E .

CELL, 1979, 18 (04) :1153-1163

[3] Emerging mechanisms of fluoroquinolone resistance [J].

Hooper, DC .

EMERGING INFECTIOUS DISEASES, 2001, 7 (02) :337-341

[4] Prevalence of plasmid-mediated quinolone resistance [J].

Jacoby, GA ;

Chow, N ;

Waites, KB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (02) :559-562

[5] Quinolone resistance from a transferable plasmid [J].

Martínez-Martínez, L ;

Pascual, A ;

Jacoby, GA .

LANCET, 1998, 351 (9105) :797-799

[6] Interaction of plasmid and host quinolone resistance [J].

Martínez-Martínez, L ;

Pascual, A ;

García, I ;

Tran, J ;

Jacoby, GA .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (04) :1037-1039

[7] Detection of the plasmid-mediated quinolone resistance determinant qnr among clinical isolates of Klebsiella pneumoniae producing AmpC-type β-lactamase [J].

Rodríguez-Martínez, JM ;

Pascual, A ;

García, I ;

Martínez-Martínez, L .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (04) :703-706

[8] Mechanism of plasmid-mediated quinolone resistance [J].

Tran, JH ;

Jacoby, GA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5638-5642

[9] Genetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China:: Role of acrR mutations [J].

Wang, H ;

Dzink-Fox, JL ;

Chen, MJ ;

Levy, SB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (05) :1515-1521

[10] Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States [J].

Wang, MG ;

Sahm, DF ;

Jacoby, GA ;

Hooper, DC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (04) :1295-1299