Non-coding RNAs: Lightning strikes twice

被引：31

作者：

Moss, EG ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 12期

关键词：

D O I：

10.1016/S0960-9822(00)00528-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A second case has been found of a nematode gene involved in developmental timing that encodes a short, non-coding RNA. Both RNAs are expressed at specific times and appear to repress target genes by interacting with their 3' untranslated regions. A coincidence? Or does this pathway attract small RNA regulators? (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：R436 / R439

页数：4

相关论文

共 16 条

[1] A HIERARCHY OF REGULATORY GENES CONTROLS A LARVA-TO-ADULT DEVELOPMENTAL SWITCH IN C-ELEGANS [J].

AMBROS, V .

CELL, 1989, 57 (01) :49-57

[2] HETEROCHRONIC MUTANTS OF THE NEMATODE CAENORHABDITIS-ELEGANS [J].

AMBROS, V ;

HORVITZ, HR .

SCIENCE, 1984, 226 (4673) :409-416

[3] Noncoding RNA genes [J].

Eddy, SR .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (06) :695-699

[4] The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans [J].

Feinbaum, R ;

Ambros, V .

DEVELOPMENTAL BIOLOGY, 1999, 210 (01) :87-95

[5] A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation [J].

Ha, I ;

Wightman, B ;

Ruvkun, G .

GENES & DEVELOPMENT, 1996, 10 (23) :3041-3050

[6] THE C-ELEGANS HETEROCHRONIC GENE LIN-4 ENCODES SMALL RNAS WITH ANTISENSE COMPLEMENTARITY TO LIN-14 [J].

LEE, RC ;

FEINBAUM, RL ;

AMBROS, V .

CELL, 1993, 75 (05) :843-854

[7] The cold shock domain protein LIN-28 controls developmental timing in C-elegans and is regulated by the lin-4 RNA [J].

Moss, EG ;

Lee, RC ;

Ambros, V .

CELL, 1997, 88 (05) :637-646

[8] The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation [J].

Olsen, PH ;

Ambros, V .

DEVELOPMENTAL BIOLOGY, 1999, 216 (02) :671-680

[9] The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans [J].

Reinhart, BJ ;

Slack, FJ ;

Basson, M ;

Pasquinelli, AE ;

Bettinger, JC ;

Rougvie, AE ;

Horvitz, HR ;

Ruvkun, G .

NATURE, 2000, 403 (6772) :901-906

[10] THE CAENORHABDITIS-ELEGANS HETEROCHRONIC GENE LIN-14 ENCODES A NUCLEAR-PROTEIN THAT FORMS A TEMPORAL DEVELOPMENTAL SWITCH [J].

RUVKUN, G ;

GIUSTO, J .

NATURE, 1989, 338 (6213) :313-319