Designer cancer vaccines are still in fashion

被引:20
作者
Biragyn, A [1 ]
Kwak, LW [1 ]
机构
[1] NCI, Dept Expt Transplantat & Immunol, Med Branch, Div Clin Sci, Bethesda, MD 20892 USA
关键词
D O I
10.1038/79649
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The use of dendritic cells to immunize against tumor antigens is improving the prospects for cancer vaccines. However, caution must be taken to avoid activating autoimmunity against normal cells (pages 1011-1017).
引用
收藏
页码:966 / 968
页数:3
相关论文
共 12 条
[1]   Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma [J].
Bendandi, M ;
Gocke, CD ;
Kobrin, CB ;
Benko, FA ;
Sternas, LA ;
Pennington, R ;
Watson, TM ;
Reynolds, CW ;
Gause, BL ;
Duffey, PL ;
Jaffe, ES ;
Creekmore, SP ;
Longo, DL ;
Kwak, LW .
NATURE MEDICINE, 1999, 5 (10) :1171-1177
[2]   Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity [J].
Biragyn, A ;
Tani, K ;
Grimm, MC ;
Weeks, S ;
Kwak, LW .
NATURE BIOTECHNOLOGY, 1999, 17 (03) :253-258
[3]   Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo [J].
Brocker, T ;
Riedinger, M ;
Karjalainen, K .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (03) :541-550
[4]   SPECIFIC ASSOCIATION OF HUMAN TELOMERASE ACTIVITY WITH IMMORTAL CELLS AND CANCER [J].
KIM, NW ;
PIATYSZEK, MA ;
PROWSE, KR ;
HARLEY, CB ;
WEST, MD ;
HO, PLC ;
COVIELLO, GM ;
WRIGHT, WE ;
WEINRICH, SL ;
SHAY, JW .
SCIENCE, 1994, 266 (5193) :2011-2015
[5]   RETRACTED: Regression of human metastatic renal cell carcinoma after vaccination with tumor cell-dendritic cell hybrids (Retracted article. See vol. 9, p. 1221, 2003) [J].
Kugler, A ;
Stuhler, G ;
Walden, P ;
Zöller, G ;
Zobywalski, A ;
Brossart, P ;
Trefzer, U ;
Ullrich, S ;
Müller, CA ;
Becker, V ;
Gross, AJ ;
Hemmerlein, B ;
Kanz, L ;
Müller, GA ;
Ringert, RH .
NATURE MEDICINE, 2000, 6 (03) :332-336
[6]   Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease [J].
Ludewig, B ;
Ochsenbein, AF ;
Odermatt, B ;
Paulin, D ;
Hengartner, H ;
Zinkernagel, RM .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (05) :795-803
[7]   Cytotoxic T cell immunity against telomerase reverse transcriptase in humans [J].
Minev, B ;
Hipp, J ;
Firat, H ;
Schmidt, JD ;
Langlade-Demoyen, P ;
Zanetti, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) :4796-4801
[8]   Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells. [J].
Nair, SK ;
Heiser, A ;
Boczkowski, D ;
Majumdar, A ;
Naoe, M ;
Lebkowski, JS ;
Vieweg, J ;
Gilboa, E .
NATURE MEDICINE, 2000, 6 (09) :1011-1017
[9]   Reciprocal control of T helper cell and dendritic cell differentiation [J].
Rissoan, MC ;
Soumelis, V ;
Kadowaki, N ;
Grouard, G ;
Briere, F ;
Malefyt, RD ;
Liu, YJ .
SCIENCE, 1999, 283 (5405) :1183-1186
[10]   The nature of the principal type 1 interferon-producing cells in human blood [J].
Siegal, FP ;
Kadowaki, N ;
Shodell, M ;
Fitzgerald-Bocarsly, PA ;
Shah, K ;
Ho, S ;
Antonenko, S ;
Liu, YJ .
SCIENCE, 1999, 284 (5421) :1835-1837