Native BK viral nephropathy in a pediatric heart transplant recipient

被引：21

作者：

Ali, Farah N. ^{[1
]}

Meehan, Shane M. ^{[2
]}

Pahl, Elfriede ^{[3
]}

Cohn, Richard A. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Pediat, Div Kidney Dis, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

[3] Northwestern Univ, Dept Pediat, Div Cardiol, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

PEDIATRIC TRANSPLANTATION | 2010年 / 14卷 / 04期

关键词：

BK virus; pediatric transplantation; post-transplant infection; viremia; polyomavirus nephropathy; POLYOMAVIRUS TYPE BK; OF-THE-LITERATURE; VIRUS NEPHROPATHY; RENAL-TRANSPLANTATION; CELL TRANSPLANTATION; KIDNEYS; INFECTION;

D O I：

10.1111/j.1399-3046.2008.01127.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BK viral nephropathy is a well-documented clinical entity in kidney transplant recipients and a significant cause of morbidity and allograft loss in affected patients. BK viral nephropathy in native kidneys of non-kidney transplant recipients is relatively uncommon, but has been reported in adult patients. We report the occurrence of BK viral nephropathy in a pediatric heart transplant recipient. A 10-yr-old boy with past history of Ewing's sarcoma underwent heart transplantation for dilated cardiomyopathy induced by previous chemotherapy with doxorubicin. Post-transplant course was complicated by grade 3A rejection and CMV colitis. He was diagnosed with native BK viral nephropathy approximately 18 months post-transplant due to mild, but persistent, elevation in serum creatinine associated with proteinuria. BK viral nephropathy affects non-kidney transplant recipients, and a high index of suspicion is necessary for early diagnosis and management of this condition.

引用

页码：E38 / E41

页数：4

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