Subgingival controlled release of antimicrobial agents in the treatment of periodontal disease

被引：44

作者：

Southard, GL ^{[1
]}

Godowski, KC ^{[1
]}

机构：

[1] Atrix Labs Inc, Ft Collins, CO 80525 USA

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 1998年 / 9卷 / 04期

关键词：

drug delivery; antibiotics; clinical; microbiology; periodontal disease;

D O I：

10.1016/S0924-8579(98)00004-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Local drug delivery of antimicrobics by sustained release delivery systems can be used to treat periodontal disease. Advantages of these systems may include biodegradation of the system, maintaining high levels of antibiotic in the gingival crevicular fluid (GCF for a sustained period of time and ease of use with high patient acceptance. This review will identify human in vivo clinical and microbiological studies. Sustained release formulations, application methods, clinical results and microbiological effects are discussed. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：239 / 253

页数：15

共 106 条

[1]

ADDY M, 1985, INT DENT J, V35, P124

[2] COMPARISON OF THE IMMEDIATE EFFECTS ON THE SUB-GINGIVAL MICROFLORA OF ACRYLIC STRIPS CONTAINING 40-PERCENT CHLORHEXIDINE, METRONIDAZOLE OR TETRACYCLINE [J].