Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor

被引:179
作者
Pham, CD
Roberts, TPL
van Bruggen, N
Melnyk, O
Mann, J
Ferrara, N
Cohen, RL
Brasch, RC [1 ]
机构
[1] Univ Calif San Francisco, Dept Radiol, Contrast Media Lab, San Francisco, CA 94143 USA
[2] Genentech Inc, Dept Neurosci, S San Francisco, CA 94080 USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
[4] Genentech Inc, Dept Cardiovasc Res, S San Francisco, CA 94080 USA
[5] Genentech Inc, Dept Mol Oncol, S San Francisco, CA 94080 USA
关键词
D O I
10.3109/07357909809039771
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Macromolecular contrast medium-enhanced magnetic resonance imaging (MRI) and tumor-volume measurements were applied to monitor the effects of anti-vascular endothelial growth factor (anti-VEGF) antibody on microvascular characteristics and tumor growth of MDA-MB-435 human breast cancer cells implanted in nude rats. Administration of anti-VEGF antibody (three 1 mg doses at 3-day intervals) induced significant reductions in tumor growth rates (p < 0.05) and in MRI-assayed microvascular permeabilities (p < 0.05). Results of the study were consistent with previous observations that new microvessels formed in response to angiogenesis are hyperpermeable, and with the hypothesis that hyperpermeability is a mechanistic element in angiogenesis. Variations in tumor-vessel hyperpermeability can be measured by contrast-enhanced MRI, which may prove useful for assessing antiangiogenesis therapy.
引用
收藏
页码:225 / 230
页数:6
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