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TRASH: a novel metal-binding domain predicted to be involved in heavy-metal sensing, trafficking and resistance

被引：66
作者：
Ettema, TJG
Huynen, MA
de Vos, WM
van der Oost, J
机构：
[1] Univ Wageningen & Res Ctr, Microbiol Lab, NL-6703 CT Wageningen, Netherlands
[2] Nijmegen Ctr Mol Life Sci, Ctr Mol & Biomol Informat, NL-6525 ED Nijmegen, Netherlands
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 04期
关键词：
D O I：
10.1016/S0968-0004(03)00037-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要：
We describe a previously undetected domain - TRASH containing a well-conserved cysteine motif that we anticipate to be involved in metal coordination. TRASH is encoded by multiple prokaryotic genomes and is present in transcriptional regulators, cation-transporting ATPases and hydrogenases, and is also present as a stand-alone module. The observed domain associations and conserved genome context of TRASH-encoding genes in prokaryotic genomes suggest that TRASH constitutes a novel component in metal trafficking and heavy-metal resistance. The role of the multiple copies of TRASH that are present in vertebrate proteins remains to be elucidated.
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页码：170 / 173
页数：4
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