Co-ordination of copper(II) by amikacin. Complexation equilibria in solution and oxygen activation by the resulting complexes

被引：40

作者：

Jezowska-Bojczuk, M ^{[1
]}

Bal, W ^{[1
]}

机构：

[1] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1998年 / 01期

关键词：

D O I：

10.1039/a704834c

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Protonation and copper(II) co-ordination properties of amikacin (A) were studied in solution by potentiometry, and NMR, UV/VIS, CD and EPR spectroscopies. Mononuclear, tetragonal and five-co-ordinate complexes of stoichiometries ranging from Cu(H(3)A) to CuH(-2)A were found. The effects of amikacin on copper(II) binding by physiological copper(II) carriers, histidine and albumin, and facilitation of oxidation of 2'-deoxyguanosine by copper(II)-amikacin complexes were also investigated. The results indicate that complexation of Cu-II by amikacin should not be expected to affect copper(II) homeostasis in blood, but may contribute to the intracellular activity of the drug.

引用

页码：153 / 159

页数：7

共 38 条

[1] 2D NMR-STUDIES OF AMINOGLYCOSIDE ANTIBIOTICS - USE OF RELAYED COHERENCE TRANSFER FOR H-1 RESONANCE ASSIGNMENT AND INSITU STRUCTURE ELUCIDATION OF AMIKACIN DERIVATIVES IN REACTION MIXTURES [J].