Functional mechanism of Ginsenosides on tumor growth and metastasis

被引：62

作者：

Chen, Tianli ^{[1
]}

Li, Bowen ^{[1
]}

Qiu, Ye ^{[1
]}

Qiu, Zhidong ^{[1
]}

Qu, Peng ^{[2
]}

机构：

[1] Changchun Univ Chinese Med, Dept Pharm, 1035 Boshuo Rd, Changchun 130117, Jilin, Peoples R China

[2] NCI, NIH, Frederick, MD 21702 USA

来源：

SAUDI JOURNAL OF BIOLOGICAL SCIENCES | 2018年 / 25卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Functional mechanism; Ginsenosides; Tumor growth; Tumor metastasis; NF-KAPPA-B; HEPATOCELLULAR-CARCINOMA CELLS; PROSTATE-CANCER CELLS; COMPOUND K; SIGNALING PATHWAY; AMERICAN GINSENG; MOLECULAR-MECHANISMS; BASEMENT-MEMBRANE; ERK1/2; PATHWAYS; CYCLE ARREST;

D O I：

10.1016/j.sjbs.2018.01.012

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Ginsengs, has long been used as one medicinal herb in China for more than two thousand years. Many studies have shown that ginsengs have preventive and therapeutic roles for cancer, and play a good complementary role in cancer treatment. Ginsenosides, as most important constituents of ginseng, have been extensively investigated and emphasized in cancer chemoprevention and therapeutics. However, the functional mechanism of Ginsenosides on cancer is not well known. This review will focus on introducing the functional mechanisms of ginsenosides and their metabolites, which regulate signaling pathways related with tumor growth and metastasis. Ginsenosides inhibit tumor growth via upregulating tumor apoptosis, inducing tumor cell differentiation and targeting cancer stem cells. In addition, Ginsenosides regulate tumor microenvironment via suppressing tumor angiogenesis-related proteins and pathways. Structural modification of ginsenosides and their administration alone or combinations with other Chinese medicines or chemical medicines have recently been developed to be a new therapeutic strategy for cancer. Production and hosting by Elsevier B.V.on behalf of King Saud University.

引用

页码：917 / 922

页数：6

共 78 条

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