Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated Neisseria meningitidis from phagocytosis by human monocytes/macrophages

被引：30

作者：

Dunn, KLR ^{[1
]}

Farrant, JL ^{[1
]}

Langford, PR ^{[1
]}

Kroll, JS ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Paediat, Mol Infect Dis Grp, Fac Med, London W2 1PG, England

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 03期

关键词：

D O I：

10.1128/IAI.71.3.1604-1607.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Superoxide dismutase cofactored by copper and zinc ([Cu,Zn]-SOD) contributes to the protection of opsonized serogroup B Neisseria meningitidis against phagocytosis by human monocytes/macrophages, with sodC mutant organisms being endocytosed in significantly higher numbers than are wild-type organisms. The influence of [Cu,Zn]-SOD was found to be exerted at the stage of phagocytosis, rather than at earlier (modulating surface association) or later (intracellular killing) stages.

引用

收藏

页码：1604 / 1607

页数：4

相关论文

共 29 条

[1] PURIFICATION AND CHARACTERIZATION OF 8 CLASS-5 OUTER-MEMBRANE PROTEIN VARIANTS FROM A CLONE OF NEISSERIA-MENINGITIDIS SEROGROUP-A [J].

ACHTMAN, M ;

NEIBERT, M ;

CROWE, BA ;

STRITTMATTER, W ;

KUSECEK, B ;

WEYSE, E ;

WALSH, MJ ;

SLAWIG, B ;

MORELLI, G ;

MOLL, A ;

BLAKE, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (02) :507-525

[2] Increased expression of periplasmic Cu,Zn superoxide dismutase enhances survival of Escherichia coli invasive strains within nonphagocytic cells [J].

Battistoni, A ;

Pacello, F ;

Folcarelli, S ;

Ajello, M ;

Donnarumma, G ;

Greco, R ;

Ammendolia, MG ;

Touati, D ;

Rotilio, G ;

Valenti, P .

INFECTION AND IMMUNITY, 2000, 68 (01) :30-37

[3] MONOCLONAL-ANTIBODIES DEMONSTRATE THAT SUPEROXIDE-DISMUTASE CONTRIBUTES TO PROTECTION OF NOCARDIA-ASTEROIDES WITHIN THE INTACT HOST [J].

BEAMAN, L ;

BEAMAN, BL .

INFECTION AND IMMUNITY, 1990, 58 (09) :3122-3128

[4] A PROTEIN ISOLATED FROM BRUCELLA-ABORTUS IS A CU-ZN SUPEROXIDE-DISMUTASE [J].

BECK, BL ;

TABATABAI, LB ;

MAYFIELD, JE .

BIOCHEMISTRY, 1990, 29 (02) :372-376

[5] Lipid modification of the Cu,Zn superoxide dismutase from Mycobacterium tuberculosis [J].

D'Orazio, M ;

Folcarelli, S ;

Mariani, F ;

Colizzi, V ;

Rotilio, G ;

Battistoni, A .

BIOCHEMICAL JOURNAL, 2001, 359 (01) :17-22

[6] Virulent Salmonella typhimurium has two periplasmic Cu, Zn-superoxide dismutases [J].

Fang, FC ;

DeGroote, MA ;

Foster, JW ;

Bäumler, AJ ;

Ochsner, U ;

Testerman, T ;

Bearson, S ;

Giárd, JC ;

Xu, YS ;

Campbell, G ;

Laessig, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (13) :7502-7507

[7] Bacterial copper- and zinc-cofactored superoxide dismutase contributes to the pathogenesis of systemic salmonellosis [J].

Farrant, JL ;

Sansone, A ;

Canvin, JR ;

Pallen, MJ ;

Langford, PR ;

Wallis, TS ;

Dougan, G ;

Kroll, JS .

MOLECULAR MICROBIOLOGY, 1997, 25 (04) :785-796

[8]

FRIDOVICH I, 1970, J BIOL CHEM, V245, P4053

[9] STUDIES ON THE MOLECULAR MECHANISMS OF HUMAN FC-RECEPTOR-MEDIATED PHAGOCYTOSIS - AMPLIFICATION OF INGESTION IS DEPENDENT ON THE GENERATION OF REACTIVE OXYGEN METABOLITES AND IS DEFICIENT IN POLYMORPHONUCLEAR LEUKOCYTES FROM PATIENTS WITH CHRONIC GRANULOMATOUS-DISEASE [J].

GRESHAM, HD ;

MCGARR, JA ;

SHACKELFORD, PG ;

BROWN, EJ .

JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (04) :1192-1201

[10] COPPER-ZINC SUPEROXIDE-DISMUTASE OF HAEMOPHILUS-INFLUENZAE AND HAEMOPHILUS-PARAINFLUENZAE [J].

KROLL, JS ;

LANGFORD, PR ;

LOYNDS, BM .

JOURNAL OF BACTERIOLOGY, 1991, 173 (23) :7449-7457