Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure

被引：50

作者：

Tonetti, DA

Morrow, M

Kidwai, N

Gupta, A

Badve, S

机构：

[1] Univ Illinois, Dept Biopharmaceut Sci, Chicago, IL 60612 USA

[2] Northwestern Univ, Dept Surg, Chicago, IL 60611 USA

[3] Northwestern Univ, Dept Pathol, Chicago, IL 60611 USA

[4] Indiana Univ, Sch Med, Dept Pathol, Indianapolis, IN 46202 USA

来源：

BRITISH JOURNAL OF CANCER | 2003年 / 88卷 / 09期

关键词：

breast cancer; tamoxifen resistance; protein kinase C alpha;

D O I：

10.1038/sj.bjc.6600923

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We previously reported that stable transfection of protein kinase C alpha (PKCalpha) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant tumour growth. Relevance of PKCalpha expression in clinical specimens was determined by comparing PKCalpha expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCalpha expression may predict TAM treatment failure. (C) 2003 Cancer Research UK.

引用

页码：1400 / 1402

页数：3

共 17 条

[1] IMMUNOLOGICAL QUANTITATION OF PHOSPHOLIPID/CA-2+-DEPENDENT PROTEIN-KINASE OF HUMAN MAMMARY-CARCINOMA CELLS - INVERSE RELATIONSHIP TO ESTROGEN-RECEPTORS [J].