Development of esophageal cancer in Chaoshan region, China: Association with environmental, genetic and cultural factors

被引:89
作者
Tang, W. R. [1 ]
Chen, Z. J. [2 ]
Lin, Kun [1 ]
Su, Min [3 ]
Au, W. W. [1 ,4 ]
机构
[1] Shantou Univ, Coll Med, Dept Prevent Med, Shantou 515041, Peoples R China
[2] Shantou Univ, Canc Hosp, Coll Med, Dept Radiat Therapy, Shantou, Peoples R China
[3] Shantou Univ, Coll Med, Dept Pathol, Shantou 515041, Peoples R China
[4] Shantou Univ, Coll Med, MPH Educ Ctr, Shantou 515041, Peoples R China
关键词
Esophageal cancer; Cigarette smoking; Genetic susceptibility; Familial cancer; Alcohol consumption; SQUAMOUS-CELL CARCINOMA; HEAT-SHOCK PROTEINS; HIGH-INCIDENCE AREA; LIFE-STYLE FACTORS; HIGH-RISK AREA; ALCOHOL-DRINKING; GREEN TEA; GEOGRAPHIC REGIONS; TOBACCO SMOKING; POLYMORPHISM;
D O I
10.1016/j.ijheh.2014.10.004
中图分类号
R1 [预防医学、卫生学];
学科分类号
100235 [预防医学];
摘要
Esophageal squamous cell carcinoma (ESCC) is the eighth most common cancer by incidence worldwide. Although the cancer is located at a readily recognizable and accessible site in the body, it is the sixth most common cause of cancer death. The 1- and 5-year survival rates in China are 50% and 15%, respectively. Furthermore, the cancer has distinct geographic and etiological risk factors in different locations around the world. Since ESCC is highly prevalent in the Chaoshan (Southeastern) region of China, this report will focus on a review of risk factors for the cancer in this area. From the review, it is clear that some important and traditional factors are involved, e.g. environmental mutagens, genetic predisposition. However, unique factors, e.g. the drinking of very hot tea, may play an important role. This review highlights the role of complex risk factors (environmental, genetic and cultural) which contribute to the multistage development of cancer: localized injury, inflammation, mitogenesis, mutagenesis, carcinogenesis and eventually mortality. The latter is contributed by unnecessary delay in seeking medical care which may be culturally related. The review emphasizes the need to identify causal mechanisms for the complex carcinogenic process which can provide opportunity for prevention and treatment of this potentially curable cancer. (C) 2014 Elsevier GmbH. All rights reserved.
引用
收藏
页码:12 / 18
页数:7
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