1-[ω-(4-arylpiperazin-1-yl)alkyl]-3-diphenylmethylene-2,5-pyrrolidinediones as 5-HT1A receptor ligands:: Study of the steric requirements of the terminal amide fragment on 5-HT1A affinity/selectivity

被引：15

作者：

López-Rodríguez, ML

Morcillo, MJ

Rovat, TK

Fernández, E

Sanz, AM

Orensanz, L

机构：

[1] Univ Complutense, Fac Ciencias Quim, Dept Quim Organ 1, Madrid 28040, Spain

[2] Univ Nacl Educ Distancia, Fac Ciencias, Madrid 28040, Spain

[3] Hosp Ramon & Cajal, Madrid 28034, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(98)00074-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present paper, we report the synthesis and the binding profile on 5-HT1A, alpha(1), and D-2 receptors of a new series of imide-arylpiperazines 3. The study oft he length of the alkyl chain and the imide substructure allows us to suggest some important differences between the no-pharmacophoric sites of both 5-HT1A and alpha(1)-adrenergic receptors, which could be of great importance in order to design new selective ligands. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：581 / 586

页数：6

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