Bile Diversion in Roux-en-Y Gastric Bypass Modulates Sodium-Dependent Glucose Intestinal Uptake

被引：86

作者：

Baud, Gregory ^{[1
,2
]}

Daoudi, Mehdi ^{[1
]}

Hubert, Thomas ^{[1
,2
]}

Raverdy, Violeta ^{[1
,2
]}

Pigeyre, Marie ^{[1
,2
]}

Hervieux, Erik ^{[1
,2
]}

Devienne, Magalie ^{[1
,2
]}

Ghunaim, Mohamed ^{[1
,2
]}

Bonner, Caroline ^{[1
,2
]}

Quenon, Audrey ^{[1
,2
]}

Pigny, Pascal ^{[3
]}

Klein, Andre ^{[4
]}

Kerr-Conte, Julie ^{[1
,2
]}

Gmyr, Valery ^{[1
,2
]}

Caiazzo, Robert ^{[1
,2
]}

Pattou, Francois ^{[1
,2
]}

机构：

[1] Univ Lille, CHU Lille, INSERM, Translat Res Diabet U1190, F-59000 Lille, France

[2] EGID, F-59000 Lille, France

[3] Univ Lille, CHU Lille, INSERM, Jean Pierre Aubert Res Ctr,U1172, F-59000 Lille, France

[4] CHU Lille, Metab & Glycosylat Dis Biol Pathol Ctr, F-59000 Lille, France

来源：

CELL METABOLISM | 2016年 / 23卷 / 03期

关键词：

DUODENAL-JEJUNAL BYPASS; BETA-CELL FUNCTION; GLYCEMIC CONTROL; SURGERY; ABSORPTION; RATS; INHIBITORS; DISPOSAL; INSULIN; DISEASE;

D O I：

10.1016/j.cmet.2016.01.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gastro-intestinal exclusion by Roux-en-Y gastric bypass (RYGB) improves glucose metabolism, independent of weight loss. Although changes in intestinal bile trafficking have been shown to play a role, the underlying mechanisms are unclear. We performed RYGB in minipigs and showed that the intestinal uptake of ingested glucose is blunted in the bile-deprived alimentary limb (AL). Glucose uptake in the AL was restored by the addition of bile, and this effect was abolished when active glucose intestinal transport was blocked with phlorizin. Sodium-glucose cotransporter 1 remained expressed in the AL, while intraluminal sodium content was markedly decreased. Adding sodium to the AL had the same effect as bile on glucose uptake. It also increased postprandial blood glucose response in conscious minipigs following RYGB. The decrease in intestinal uptake of glucose after RYGB was confirmed in humans. Our results demonstrate that bile diversion affects postprandial glucose metabolism by modulating sodium-glucose intestinal cotransport.

引用

页码：547 / 553

页数：7

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