Synergistic effect of HLA class II loci and cytokine gene polymorphisms on the risk of gastric cancer in Japanese patients with Helicobacter pylori infection

被引：28

作者：

Ando, Takashi ^{[1
,2
]}

Ishikawa, Takeshi ^{[2
]}

Kato, Haruki ^{[2
]}

Yoshida, Norimasa ^{[2
]}

Naito, Yuji ^{[2
]}

Kokura, Satoshi ^{[2
]}

Yagi, Nobuaki ^{[2
]}

Takagi, Tomohisa ^{[2
]}

Handa, Osamu ^{[2
]}

Kitawaki, Jo ^{[3
]}

Nakamura, Naoto ^{[4
]}

Hasegawa, Goji ^{[4
]}

Fukui, Michiaki ^{[4
]}

Imamoto, Eiko ^{[1
]}

Nakamura, Chie ^{[1
]}

Oyamada, Hirokazu ^{[5
]}

Isozaki, Yutaka ^{[5
]}

Matsumoto, Naohito ^{[5
]}

Nagao, Yasuyuki ^{[5
]}

Okita, Mika ^{[5
]}

Nakajima, Yoshihiro ^{[6
]}

Kurokawa, Manabu ^{[7
]}

Nukina, Masafumi ^{[7
]}

Ohta, Mitsuhiro ^{[8
]}

Mizuno, Shigeto ^{[9
]}

Ogata, Masakazu ^{[10
]}

Obayashi, Hiroshi ^{[10
]}

Park, Hyohun ^{[11
]}

Kitagawa, Yoshihiro ^{[12
]}

Nakano, Koji ^{[13
]}

Yoshikawa, Toshikazu ^{[2
]}

机构：

[1] Social Insurance Kyoto Hosp, Dept Gastroenterol, Kita Ku, Kyoto 6038151, Japan

[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Mol Gastroenterol & Hepatol, Kyoto, Japan

[3] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Obstet & Gynecol, Kyoto, Japan

[4] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto, Japan

[5] Matsushita Mem Hosp, Dept Gastroenterol, Osaka, Japan

[6] Matsushita Mem Hosp, Dept Cent Lab, Osaka, Japan

[7] Kobe Inst Hlth, Dept Microbiol, Kobe, Hyogo, Japan

[8] Kobe Pharmaceut Univ, Dept Med Biochem, Kobe, Hyogo 658, Japan

[9] Kobe Pharmaceut Univ, Dept Med Pharmaceut, Kobe, Hyogo 658, Japan

[10] Inst Bioresponse Informat, Dept Mol Biol, Kyoto, Japan

[11] Saiseikai Suita Hosp, Dept Internal Med, Osaka, Japan

[12] W Japan Railway Co, Osaka Gen Hosp, Dept Internal Med, Osaka, Japan

[13] Yamashiro Publ Hosp, Dept Internal Med, Kyoto, Japan

来源：

INTERNATIONAL JOURNAL OF CANCER | 2009年 / 125卷 / 11期

关键词：

gastric cancer; Helicobacter pylori; polymorphic variation; HLA class II alleles; cytokines; ASSOCIATION; ADENOCARCINOMA; POPULATION; INTERLEUKIN-10; CARCINOMA; PROMOTER; RECEPTOR; REGION; SUSCEPTIBILITY; ENDOMETRIOSIS;

D O I：

10.1002/ijc.24666

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It has been reported that polymorphisms of human leukocyte antigen (HLA) genes and several cytokine genes are associated with an increased risk of developing gastric cancer (GC). However, the results of studies from different geographic regions, ethnic groups and study groups are inconsistent. The aim of this study was to evaluate the influence of H. pylori infection and host genetic factors on GC susceptibility in Japanese patients with GC. We analyzed genotypes for HLA class I and II, tumor necrosis factor alpha, interleukin (IL)-1 beta, IL-1 receptor, IL-4, IL-4R alpha and IL-10 in 330 H. pylori-infected noncardia patients with GC and 190 H. pylori-infected nonulcer dyspeptic controls. Haplotype analyses indicated that the frequencies of the HLA DRB1*0405 and DQB1*0401 alleles were increased in the patients with intestinal-type GC when compared with controls (both DRB1*0405 and DQB1*0401: p = 0.015, OR = 1.57, 95% CI = 1.09-2.26), but the changes were not statistically significant after correction for multiple comparisons. None of the cytokine gene polymorphisms were associated with GC susceptibility, whether patients with GC were analyzed as a group according to the histological subtype. Of interest was the comparison of controls and patients with intestinal-type GC. The frequency of an IL-10-592AA homozygote showing concomitant carriage of the HLA DRB1*0405-DQB1*0401 haplotype was significantly higher in patients with intestinal-type GC (chi(2) = 6.369, p = 6.0116, p(c) = 0.0464, OR = 2.43, 95% CI = 1.21-4.48). Our results suggest that the HLA class II and IL-10-592A/C polymorphisms synergistically affect the susceptibility to GC development of H. pylori-infected individuals in the Japanese population. (c) 2009 UICC

引用

页码：2595 / 2602

页数：8

共 42 条

[1] Association of interleukin-1B and interleukin-1RN polymorphisms with gastric cancer in a high-risk population of Costa Rica [J].

Alpízar-Alpízar, W ;

Pérez-Pérez, GI ;

Une, C ;

Cuenca, P ;

Sierra, R .

CLINICAL AND EXPERIMENTAL MEDICINE, 2005, 5 (04) :169-176

[2]

Azuma T, 1998, CANCER, V82, P1013, DOI 10.1002/(SICI)1097-0142(19980315)82:6<1013::AID-CNCR2>3.0.CO

[3]

2-F

[4] Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST) [J].

Crusius, J. B. A. ;

Canzian, F. ;

Capella, G. ;

Pena, A. S. ;

Pera, G. ;

Sala, N. ;

Agudo, A. ;

Rico, F. ;

Del Giudice, G. ;

Palli, D. ;

Plebani, M. ;

Boeing, H. ;

Bueno-de-Mesquita, H. B. ;

Carneiro, F. ;

Pala, V. ;

Save, V. E. ;

Vineis, P. ;

Tumino, R. ;

Panico, S. ;

Berglund, G. ;

Manjer, J. ;

Stenling, R. ;

Hallmans, G. ;

Martinez, C. ;

Dorronsoro, M. ;

Barricarte, A. ;

Navarro, C. ;

Quiros, J. R. ;

Allen, N. ;

Key, T. J. ;

Binghan, S. ;

Caldas, C. ;

Linseisen, J. ;

Kaaks, R. ;

Overvad, K. ;

Tjonneland, A. ;

Buechner, F. C. ;

Peeters, P. H. M. ;

Numans, M. E. ;

Clavel-Chapelon, F. ;

Trichopoulou, A. ;

Lund, E. ;

Jenab, M. ;

Rinaldi, S. ;

Ferrari, P. ;

Riboli, E. ;

Gonzalez, C. A. .

ANNALS OF ONCOLOGY, 2008, 19 (11) :1894-1902

[5] The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer (vol 404, pg 398, 2000) [J].

El-Omar, EM ;

Carrington, M ;

Chow, WH ;

McColl, KEL ;

Bream, JH ;

Young, HA ;

Herrera, J ;

Lissowska, J ;

Yuan, CC ;

Rothman, N ;

Lanyon, G ;

Martin, M ;

Fraumeni, JF ;

Rabkin, CS .

NATURE, 2001, 412 (6842) :99-+

[6] Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms [J].

El-Omar, EM ;

Rabkin, CS ;

Gammon, MD ;

Vaughan, TL ;

Risch, HA ;

Schoenberg, JB ;

Stanford, JL ;

Mayne, ST ;

Goedert, J ;

Blot, WJ ;

Fraumeni, JF ;

Chow, WH .

GASTROENTEROLOGY, 2003, 124 (05) :1193-1201

[7]

FORMAN D, 1993, LANCET, V341, P1359

[8] Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites:: A nationwide multicenter study in Spain [J].

Garcia-Gonzalez, Maria Asuncion ;

Lanas, Angel ;

Quintero, Enrique ;

Nicolas, David ;

Parra-Blanco, Adolfo ;

Strunk, Mark ;

Benito, Rafael ;

Simon, Miguel Angel ;

Santolaria, Santos ;

Sopena, Federico ;

Piazuelo, Elena ;

Jimenez, Pilar ;

Pascual, Cristina ;

Mas, Eva ;

Irun, Pilar ;

Espinel, Jesus ;

Campo, Rafael ;

Manzano, Marisa ;

Geijo, Fernando ;

Pellise, Maria ;

Gonzalez-Huix, Ferran ;

Nieto, Miguel ;

Espinos, Jorge ;

Tito, LLucia ;

Bujanda, Luis ;

Zaballa, Manuel .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2007, 102 (09) :1878-1892

[9] Interleukin-1β polymorphisms, Helicobacter pylori infection in individuals from Northern Brazil with gastric adenocarcinoma [J].

Gatti, LL ;

Burbano, RR ;

de Assumpçao, PP ;

Smith, MDC ;

Payao, SLM .

CLINICAL AND EXPERIMENTAL MEDICINE, 2004, 4 (02) :93-98

[10] GENE-FREQUENCIES AND HAPLOTYPIC ASSOCIATIONS WITHIN THE HLA REGION IN 916 UNRELATED JAPANESE INDIVIDUALS [J].

HASHIMOTO, M ;

KINOSHITA, T ;

YAMASAKI, M ;

TANAKA, H ;

IMANISHI, T ;

IHARA, H ;

ICHIKAWA, Y ;

FUKUNISHI, T .

TISSUE ANTIGENS, 1994, 44 (03) :166-173

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