An evaluation of the efficacy of vasoactive intestinal polypeptide antagonists in vivo in the anaesthetized dog

被引：10

作者：

Markos, F ^{[1
]}

Hennessy, BA ^{[1
]}

Fitzpatrick, M ^{[1
]}

O'Sullivan, J ^{[1
]}

Snow, HM ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Dept Physiol, Cork, Ireland

来源：

PHARMACOLOGY | 2002年 / 66卷 / 04期

关键词：

VIP antagonists; VIP (6-28); D-p-Cl-Phe(6); Leu(17)]-VIP; PACAP (6-27); heart; dog;

D O I：

10.1159/000065535

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effectiveness of competitive peptide vasoactive intestinal polypeptide (VIP) receptor antagonists was evaluated on heart rate in the anaesthetized dog. Two specific antagonists, VIP (6-28) and [D-p-Cl-Phe(6), Leu(17)]-VIP, and a nonspecific antagonist, pituitary adenylate cyclase activating peptide fragment (6-27) (PACAP), were studied. VIP (6-28) and [D-p-Cl-Phe(6), Leu(17)]-VIP (100 mug i.c.) increased the heart rate, whereas PACAP (100 mug i.c.) reduced the baseline heart rate. All three shifted the VIP dose-response curve to the right by two- to threefold for 30 min. In conclusion, PACAP, VIP (6-28), and [D-p-Cl-Phe(6), Leu(17)]-VIP have a direct effect on the heart rate, are equally effective, and the effects last approximately 30 min in vivo. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：206 / 210

页数：5

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