Antiinflammatory and Lipoxygenase Inhibitory Compounds from Vitex agnus-castus

被引：67

作者：

Choudhary, M. Iqbal ^{[1
]}

Azizuddin ^{[1
]}

Jalil, Saima ^{[1
]}

Nawaz, Sarfraz Ahmad ^{[1
]}

Khan, Khalid Mohammed ^{[1
]}

Tareen, Rasool Bakhsh ^{[2
]}

Atta-ur-Rahman ^{[1
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

[2] Univ Baluchistan, Dept Bot, Quetta, Pakistan

来源：

PHYTOTHERAPY RESEARCH | 2009年 / 23卷 / 09期

关键词：

Vitex agnus-castus; Verbenaceae; antiinflammatory activity; lipoxygenase inhibitory activity; flavonoids; phenolic derivatives; DRUGS; ACID;

D O I：

10.1002/ptr.2639

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Several secondary metabolites, artemetin (1), casticin (2), 3,3'-dihydroxy-5,6,7,4'-tetramethoxy flavon (3), penduletin (4), methyl 4-hydroxybenzoate (5), p-hydroxybenzoic acid (6), methyl 3,4-dihydroxybenzoate (7), 5-hydroxy-2-methoxybenzoic acid (8), vanillic acid (9) and 3,4-dihydroxybenzoic acid (10) were isolated from a folkloric medicinal plant, Vitex agnus-castes. The structures of compounds 1-10 were identified with the help of spectroscopic techniques. Compounds 3-10 were isolated for the first time from this plant. These compounds were screened for their antiinflammatory and lipoxygenase inhibitory activities. Compounds 6, 7 and 10 were found to have significant anti inflammatory activity in a cell-based contemporary assay, whereas compounds 1 and 2 exhibited a potent lipoxygenase inhibition. Copyright (c) 2009 John Wiley & Sons, Ltd.

引用

页码：1336 / 1339

页数：4

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