Thrombotic thrombocytopenic purpura in a newborn

被引：15

作者：

Paul T Jubinsky

Richard Moraille

Han-Mou Tsai

机构：

[1] Div. Pediatric Hematology/Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461

[2] Division of Hematology/Oncology, Children's Hospital Medical Center, Cincinnati, OH

[3] Division of Neonatology, Children's Hospital Medical Center, Cincinnati, OH

[4] Division of Hematology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY

来源：

Journal of Perinatology | 2003年 / 23卷 / 1期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/sj.jp.7210853

中图分类号：

学科分类号：

摘要：

The report describes a newborn who presented with hyperbilirubinemia and thrombocytopenia. The patient recovered after treatment with antibiotics, phototherapy, and a platelet transfusion. Analysis of the plasma von Willebrand factor-cleaving metalloprotease, ADAMTS13, revealed low protease activity in the patient and her two siblings, and a mild deficiency in both parents. These results confirmed the clinical suspicion of hereditary thrombotic thrombocytopenic purpura (TTP). Although most cases of thrombocytopenia and hyperbilirubinemia in the newborn period are caused by other causes, genetic deficiency of ADAMTS13 may not be as uncommon as previously believed. Early diagnosis may have important implications for the patients.

引用

页码：85 / 87

页数：2

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