Translocation t(6;14) as the Sole Chromosomal Abnormality in Adenoid Cystic Carcinoma of the Base of Tongue

被引：6

作者：

Bell D. ^{[1
]}

Zhao Y.-J. ^{[2
]}

Rao P.H. ^{[2
]}

Weber R.S. ^{[3
]}

El-Naggar A.K. ^{[1
,4
]}

机构：

[1] Department of Pathology, Unit 85, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030

[2] Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030, 6621 Fannin Street

[3] Department of Head and Neck Surgery, Unit 0441, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030

[4] Department of Pathology and Head and Neck Surgery, Unit 85, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030

来源：

Head and Neck Pathology | 2007年 / 1卷 / 2期

关键词：

Adenoid cystic carcinoma; Comparative genomic hybridizations; Cytogenetic; Spectral karyotyping; Translocations;

D O I：

10.1007/s12105-007-0030-5

中图分类号：

学科分类号：

摘要：

We present an adenoid cystic carcinoma of the base of tongue in a 48-year-old male with a restricted chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). SKY and G-banding analyses identified the t(6;14)(q25;q13) as the sole structural aberration in all metaphases analyzed. This finding supports a critical role for this event in the development of this tumor. The implications of chromosome 6q translocation in this case and in previously reported adenoid cystic carcinomas are highlighted and discussed. © Humana Press Inc. 2007.

引用

页码：165 / 168

页数：3

共 32 条

[21]

Stallmach I., Zenklusen P., Komminoth P., Et al., Loss of heterozygosity at chromosome 6q23-25 correlates with clinical and histologic parameters in salivary gland adenoid cystic carcinoma, Virchows Arch, 440, pp. 77-84, (2002)

[22]

Johns M.M., Westra W.H., Califano J.A., Et al., Allelotype of salivary gland tumors, Cancer Res, 56, pp. 1151-1154, (1996)

[23]

Kishi M., Nakamura M., Nishimine M., Et al., Loss of heterozygosity on chromosome 6q correlates with decreased thrombospondin-2 expression in human salivary gland carcinomas, Cancer Sci, 94, pp. 530-535, (2003)

[24]

Berger R., Bloomfield C.D., Sutherland G.R., Report of the committee on chromosome rearrangements in Neoplasia and on Fragile sites, Cytogenet Cell Genet, 40, pp. 490-535, (1985)

[25]

Harper M.E., Franchini G., Love J., Et al., Chromosomal sublocalization of human c-myb and c-fes cellular onc genes, Nature, 304, pp. 169-171, (1983)

[26]

Yoshida M.C., Satoh H., Sasaki M., Et al., Regional location of a novel yes-related proto-oncogene, syn, on human chromosome 6 at band q21, Jpn J Cancer Res, 77, pp. 1059-1061, (1986)

[27]

Yoshida M.C., Satoh H., Matsushime H., Shibuya M., Sasaki M., Two ras-related proto oncogenes, c-ros-1 and 8H, are regionally mapped on chromosomes 6q22 and 13q12, respectively. Ninth International Workshop on Human Gene Mapping 9, Cytogenet Cell Genet, 46, (1987)

[28]

Wong K.F., 11q13 is a cytogenetically promiscuous site in hematologic malignancies, Cancer Genet Cytogenet, 113, pp. 93-95, (1999)

[29]

Rabbitts T.H., Chromosomal translocations in human cancer, Nature, 372, pp. 143-149, (1994)

[30]

Lastowska M., Roberts P., Pearson A.D., Et al., Promiscuous translocations of chromosome arm 17q in human neuroblastomas, Genes Chromosomes Cancer, 19, pp. 143-149, (1997)

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